Blood samples in test-tubes

An article in the Journal of Orthopaedic & Sports Physical Therapy April 2014 indicates that spinal manipulation causes an increase in neurotensin, oxytocin, and cortisol immediately after the adjustment.

The study took 30 asymptomatic volunteers and put them into lumber, thoracic, and cervical manipulation groups.

Each group had blood drawn before, immediately after, and then 2 hour after a spinal adjustment.

The neurotensin and oxytocin were increased in all three groups, and the cortisol was increased with cervical manipulation. So what does this mean?


What are the Effects of Neurotensin, Oxytocin, and Cortisol?

  • Has¬†analgesic effects helping to reduce pain
  • Produces a spectrum of pharmacological effects resembling those of anti-psychotic drugs
  • Modulates the activity in the small intestine
  • Blocks production of stomach acid



  • A primary neuromodulator in the brain
  • Reduces inflammation
  • Improves wound healing
  • Increases trust and reduces fear in social interactions


  • Activates anti-stress pathways
  • Activates anti-inflammatory pathways
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